Figure 6.

Animal tumor metastasis experiments show CAS regulates the metastasis of B16-F10 melanoma cells. Eleven B16-EV cells-injected mice and six B16-anti-CAS cells-injected mice passed away three weeks after injection thus were excluded from the statistics. Six mice (three B16-EV cells-injected mice and three B16-anti-CAS cells-injected mice) didn't grow tumour in lungs and thus were also excluded from the statistics. The results showed that reduced CAS expression inhibited the pulmonary tumour metastasis of B16-F10 melanoma cells in C57BL/6 mice.