Table 7

A list of studies of surgical treatment and quality o life in breast cancer patients (1974–2007)

Author (s) [Ref.]

Year

Treatment (assessment time)

Conclusion(s)


de Haes et al. [85]

1985

MAS vs. tumorectomy (11 months after surgery)

No differences expect worse body image in MAS patients.


de Haes et al. [86]

1986

MAS vs. tumorectomy (11 and 18 months after surgery)

Overall QOL improved over time in both groups; poor body image in MAS.


Ganz et al. [87]

1992

MAS vs. BCS after one year

No significant differences in QOL and both groups improved; BCS patients did not experience significantly better QOL but had fewer problems with clothing and body image.


Shimozuma et al. [88]

1994

Surgery-any

Hospitalization had a strong negative relation to overall QOL; type of surgery had no significant association with QOL.


Neises et al. [89]

1994

MAS or BCS

Older women suffer as much as younger patients after MAS.


Fallowfield [90]

1994

Surgery and tamoxifen vs. tamoxifen alone

At 2 years similar psychological health; no evidence of impaired QOL for elderly women after surgery


Shimozuma et al. [91]

1995

MRM or BCS (before surgery and 3 times up 2 years after)

No significant differences in overall QOL; patients with BCS need more psychological support.


Hart et al. [92]

1997

MAS + prostheses or MAS + reconstruction or MAS alone

No one technique is necessary for all women to optimize QOL; women should choose and make their own decisions.


Dorval et al. [93]

1998

Partial or total MAS (3 and 18 months after)

Both appeared to be equivalent in long-term QOL. Younger women might benefit more from partial MAS.


Curran et al. [94]

1998

MRM vs. BCS

Significant benefit in body image and satisfaction in BCS group; no difference in fear of recurrence.


Wapnir et al. [95]

1999

Lumpectomy with axillary dissection (LAD) or mastectomy

No major differences except for dressing, comfort with nudity and sexual drive in favor of ALD.


Shimozuma et al. [96]

1999

MRM or BCS (1 year after)

At one year good QOL, with no relationship to the type of surgery.


Pusic et al. [97]

1999

Lumpectomy + irradiation or MAS + reconstruction or MAS alone

Postoperative QOL varied with age; for age less than 55 QOL was lowest for MAS, over 55 was lowest for lumpectomy.


Amichetti et al. [98]

1999

BCS + irradiation in non-infiltrating breast cancer

Good QOL and body image and lack of negative impact on sexuality.


King et al. [99]

2000

MAS or BCS (3 months and 1 year after)

Most symptoms declined over time but arm and menopausal symptoms persisted; worse QOL in younger patients.


Kenny et al. [100]

2000

MAS or BCS + irradiation (1 year after)

Better body image and physical function in BCS; more impact on younger women regardless of treatment type.


Nissen et al. [101]

2001

MAS or MAS + reconstruction or BCS (6 times assessment up to 2 years after)

QOL other than body image were not better in BCS or MAS + reconstruction than in who had MAS alone; MAS + reconstruction was associated with greater mood disturbance and poorer QOL.


Janni et al. [102]

2001

MAS or BCS (median 46 months follow-up)

Surgical modalities had no long-term impact on overall QOL, but certain body image related problems in MAS was observed.


Girotto et al. [103]

2003

MAS + reconstruction in older women

Improved QOL in older patients especially improved mental health.


Cocquyt et al. [104]

2003

Skin-sparing MAS or BCS

Both yielded comparable QOL, but cosmetic outcome was better after skin-sparing MAS.


Engel et al [105]

2004

MAS or BCS (5 years follow-up)

MAS patients had lower body image, role and sexual functioning; BCS should be encouraged in all ages.


Ganz et al. [106]

2004

Lumpectomy + chemotherapy or MAS + chemotherapy or Lumpectomy alone or MAS alone in non-metastatic breast cancer patients

At the end of primary treatment all treatment groups reported good emotional functioning but decreased physical health especially among women who had MAS or received chemotherapy.


Dubernard et al. [107]

2004

SLNB

Axillary procedure affected only QOL related to arm morbidity.


Elder et al. [108]

2005

MAS + immediate breast reconstruction (before and 12 months after)

After 12 months good QOL comparable with aged-matched women from the general population.


Barranger et al. [109]

2005

SLNB vs. ALND in breast-sparing treatment

SLNB was associated with significantly lower mid term morbidity.


Fleissig [110]

2006

SLNB vs. ALND

Regarding arm functioning and QOL the use of SNB was recommended in patients with node negative breast cancer.


Pandey et al. [111]

2006

MAS or BCS

No significant change in overall QOL after surgery; poorer QOL in MAS patients.


Rietman et al. [112]

2006

SLNB or ALND (before and after 2 years)

Less treatment related upper limb morbidity, perceived disability in activities of daily life and worsening of QOL after SNLB compared with ALND.


Parker et al. [113]

2007

MAS or MAS+ reconstruction or BCS (short- and long-term effects on aspects of psychosocial adjustment and QOL

Overall, the general patterns of psychosocial adjustment and QOL were similar among the three surgery groups.


Abbreviations

MRM: modified radical mastectomy, MAS: mastectomy, BCS: breast conservation surgery, SNLB: sentinel lymph node biopsy, ALND: axillary lymph node dissection

Montazeri Journal of Experimental & Clinical Cancer Research 2008 27:32   doi:10.1186/1756-9966-27-32

Open Data