Figure 7.

Cilengitide induces disassembly of tight junctions and actin cytoskeleton in endothelial and glioma cells. HMEC-1 (left panel) or G28 cells (right panel) were treated with full medium (A-D) or cilengitide at concentrations of 1 μg/ml (E-H) and 5 μg/ml (I-L) in full medium for 24 hours. Cells were then fixed and stained for ZO-1 (green) and actin (red).