Review

Adjuvant electrochemotherapy in veterinary patients: a model for the planning of future therapies in humans

Enrico P Spugnini¹ , Gennaro Citro¹ and Alfonso Baldi²

¹  S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy

²  Department of Biochemistry, section of Pathology, Second University of Naples, Naples, Italy

author email corresponding author email

Journal of Experimental & Clinical Cancer Research 2009, 28:114doi:10.1186/1756-9966-28-114

Published:	14 August 2009

Abstract

The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperative, intraoperative, or postoperative. In selected patients adjuvant brachytherapy can be adopted. The goal of these associations is to achieve tumor control while maximally preserving the normal tissues from side effects. Unfortunately, the occurrence of local and distant complications is still elevated. Electrochemotherapy is a novel technique that combines the administration of anticancer agents to the application of permeabilizing pulses in order to increase the uptake of antitumor molecules. While its use in humans is still confined to the treatment of cutaneous neoplasms or the palliation of skin tumor metastases, in veterinary oncology this approach is rapidly becoming a primary treatment. This review summarizes the recent progresses in preclinical oncology and their possible transfer to humans.