Alcohol induces cell invasion by suppressing Nm23 expression. T47D cells were treated with 0.5% v/v alcohol and the expression of known metastasis suppressor genes was determined by qRT-PCR. Nm23 mRNA expression levels significantly decreased following treatment. KAI1, RRM1, and BRMS1 expression were not affected by alcohol and expression of KISS1 and Mkk4 were increased by alcohol. (*p < 0.05, as compared to the control cells with no alcohol treatment).
Wong et al. Journal of Experimental & Clinical Cancer Research 2011 30:75 doi:10.1186/1756-9966-30-75