Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients
1 Department of Respiratory Medicine, Second Affiliated Hospital, Xi’an Jiaotong University, 157, Xi 5 Road, Xi’an, 710004, People's Republic of China
2 Department of Oncology, Weinan Central Hospital, Weinan, China
3 Department of Respiratory Medicine, People’s Hospital of Gansu Province, Lanzhou, China
4 Department of Pathology, People’s Hospital of Gansu Province, Lanzhou, China
Journal of Experimental & Clinical Cancer Research 2012, 31:70 doi:10.1186/1756-9966-31-70Published: 28 August 2012
Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and annexin A1 in lung cancer and normal lung specimens were examined, and the relationships with respect to the clinico-pathological features and patient survival in lung cancer were analyzed.
The expression levels of Hsp90-beta and annexin A1 were examined using immunohistochemistry, in-situ hybridization, and Western blot.
Lung cancer tissues exhibited higher expression levels of Hsp90-beta and annexin A1 than the normal tissues (p < 0.05), and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of lung cancer (p < 0.05). Moreover, the upregulation of Hsp90-beta and annexin A1 correlated with decreased survival (p < 0.05).
The upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients. Moreover, the high expression of the markers was an independent predictor of poor outcomes.