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Open Access Research

Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma

Xiao-Lin Zhu12, Zhang-Feng Wang12, Wen-Bin Lei12, Hui-Wen Zhuang12, Wei-Jian Hou12, Yi-Hui Wen12 and Wei-Ping Wen12*

Author Affiliations

1 Department of Otorhinolaryngology Head and Neck surgery, The First Affiliated Hospital, Sun Yat-Sen University, 2nd Zhongshan Road 58#, Guangzhou, 510080, Guangdong, P.R. China

2 Otorhinolaryngology Institute, Sun Yat-Sen University, 2nd Zhongshan Road 58#, Guangzhou, 510080, Guangdong, P.R. China

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Journal of Experimental & Clinical Cancer Research 2012, 31:94  doi:10.1186/1756-9966-31-94

Published: 14 November 2012

Abstract

Background

DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. However, the tumorigenesis role and clinical significance of DJ-1 in supraglottic squamous cell carcinoma (SSCC) is unclear. We aimed to evaluate the DJ-1 the relationship between DJ-1 and clinicopathological data including patient survival.

Methods

The expression of DJ-1 and PTEN in SSCCs (52) and adjacent non-cancerous tissues (42) was assessed by immunohistochemistry (IHC), and the relationship between DJ-1 and clinicopathological data was analyzed.

Results

DJ-1 was detected mainly in SSCCs (88.5%) and less frequently in adjacent non-cancerous tissues (21.0%). PTEN expression was detected in 46.2% of SSCCs and in 90.5% of adjacent non-cancerous tissues. DJ-1 expression was linked to nodal status (Pā€‰=ā€‰0.009), a highly significant association of DJ-1 expression with shortened patient overall survival (5-year survival rate 88.0% versus 53.9%; Pā€‰=ā€‰0.007; log rank test) was demonstrated.

Conclusions

Our data suggested that DJ-1 over-expression was linked to nodal status, and might be an independent prognostic marker for patients with SSCC.

Keywords:
DJ-1; PTEN; Tumorigenesis; Supraglottic squamous cell carcinoma; Overall survival