Comment on: Escudero-Esparza et al. Journal of Experimental & Clinical Cancer Research, 31:43
Correction for 13C-NMR data of EPA (Colin Charles Duke, 20 March 2011)
The 15 numbers for the 13C-NMR data of EPA are, in error, shown in the article as being the same as EPD. The correction is as follows:- Eremophila-1(10),11(13)-dien-12-oic acid (EPA) 13C-NMR (CDCl3): 15.96, 20.71, 25.34, 27.00, 28.05, 30.41, 32.63, 36.24, 38.08, 40.50, 121.36, 124.72, 142.96, 145.12, 172.85. read full comment
Comment on: van Haaften et al. Journal of Experimental & Clinical Cancer Research, 30:29
Comment on: She et al. Journal of Experimental & Clinical Cancer Research, 29:93
INCIDENCE OF BREAST CANCER IN ITALY: WHY HOSPITALIZATION RECORDS ARE A VALUABLE OPPORTUNITY (Prisco Piscitelli, 20 July 2009)
Although Cancer Registries remain the gold standard for epidemiologic evaluation of tumors, unfortunately they are not currently available in all Italian provinces. Therefore, in order to evaluate the incidence of neoplastic lesions at national level (as declared in its publications), the Italian Association of Cancer Registries must use other data sources (such as mortality rates provided by the National Instiute for Statistics, ISTAT) or refer to average values determined within the few existing registries (actually 70% of Italian population is not being covered by cancer registries). This means that national data concerning the incidence of cancers in Italy are the result of average estimations or statistical models and do not reflect a real "count" of overall cases. On the other hand...
read full comment
Comment on: Piscitelli et al. Journal of Experimental & Clinical Cancer Research, 28:86
Link to a lay summary of this research paper (Gustav Nilsonne, 20 July 2009)
A short non-technical description of this research is available on my blog at this link. read full comment
Comment on: Nilsonne et al. Journal of Experimental & Clinical Cancer Research, 28:92
Trend assesment by comparison with a Cancer Registry (Paolo Contiero, 05 July 2009)
I have carefully read the paper, interesting because present a method to estimates breast cancer incidence, a so important topic for health service planning and primary prevention researches. In my opinion, the weakness of this paper is the lack of a gold standard by which validate the method and its results. This could lead to the introduction of some bias in the estimates that are not possible to detect easily. By this notes I show some data from the Cancer Registry of Varese and the hospital discharges of the same area. The Cancer Registry of Varese began its activity in 1976 and its data was included in the last four editions of the Cancer Incidence in Five Continents. The Cancer Registry data are linked with the hospital discharge (SDO), pathology report and...
read full comment
Comment on: Piscitelli et al. Journal of Experimental & Clinical Cancer Research, 28:86
Answer to comments of prof. Koninckx (Alfonso Baldi, 07 June 2009)
Dear Editor, We are very happy that our work is raising great interest in the scientific community (see for example Faculty of 1000 Medicine: evaluations for Signorile PG et al J Exp Clin Cancer Res 2009 28 :49 http://www.f1000medicine.com/article/id/1160737/evaluation). We thank dr. Koninckx and colleagues for their comments on our paper supporting the embryological origin of endometriosis (1). Indeed, we have really appreciated some of the comments that will help us in our future investigations. Nevertheless, we strongly disagree with some of the claims of our colleagues. We will try to follow point-by-point their letter in order to clarify the issues raised. The colleagues complain the absence of pictures or data of the endometrium. It is surprisingly that the colleagues...
read full comment
Comment on: Signorile et al. Journal of Experimental & Clinical Cancer Research, 28:49
Ectopic endometrium in the human foetus (Müllerianosis) must be interpreted cautiously (Philippe R. Koninckx, 27 May 2009)
Dear Editor, We read with great interest the nice observations by Signorile et al. of endometrium-like tissue in foetuses supporting the concept of müllerianosis. (1) The data, however, poorly support the speculative and overstretched conclusions. The title is misleading and the discussion partially incorrect. In the absence of pictures or data of the endometrium and of the expression of estrogen receptors it is difficult to judge how specific this observation was. We therefore would be interested to have more information about the specificity of these markers and whether these markers were positive in all endometrium tissue. It is surprising not to find the word CA125, or the words ‘estrogen receptor’ in reference 1 quoted to support the choice of CA125 and of...
read full comment
Comment on: Signorile et al. Journal of Experimental & Clinical Cancer Research, 28:49
Answer to the comment: Mulleriosis and not Mullerianosis by dr. Redwine (Alfonso Baldi, 14 May 2009)
Dear Editor, we have really appreciated the positive comments of dr. Redwine on our paper recently published in your journal (J Exp Clin Cancer Res 2009; 28:49). We are very happy that our discoveries on the pathogenesis of endometriosis raise the interest of the other scientists involved in this field of research. Concerning the question raised by dr. Redwine on the exact term to use for defining this phenotype, we used the term Mullerianosis, because it is the one mostly used by researcher to define this condition, while the term Mulleriosis has been used only by dr. Redwine (Letter to Am J Obstet Gynecol 1987; 156:769); anyway we have no any problem in using also this term in our next publications. Nevertheless, we think that the most important point of our manuscript is, as also...
read full comment
Comment on: Signorile et al. Journal of Experimental & Clinical Cancer Research, 28:49
Mulleriosis not Mullerianosis (David Redwine, 13 May 2009)
I read with great interest the recently published paper by Signorile et al (1). They found evidence of endometriosis in 4 of 36 (11%) female foetuses examined with step-sectioning of the posterior pelvis. They correctly conclude that endometriosis begins in foetal life and is not a product of reflux menstruation. Their work supports my work published in 1988 (2), where I found apparent endometriosis in the cul de sac of 1 of 9 (11%) newborn females who died of sudden infant death syndrome, although my work was not mentioned in the authors' reference list. I would suggest that "Mulleriosis" would be a better term than "Mullerianosis" for this ontogenic development. First, "Mulleriosis" as an overarching term to describe the foetal...
read full comment
Comment on: Signorile et al. Journal of Experimental & Clinical Cancer Research, 28:49
GenBank Accession No should be corrected (Haiyan Liu, 26 February 2009)
Dear editor, I’ m sorry for my mistake. B 4.1 Knockdown of AEG-1 expression was achieved using transfection of AEG-1-siRNA. AEG-1-siRNA1 and AEG-1-siRNA2 targeting nucleotides 971-991 and 1355-1375 of human AEG-1 mRNA sequence (GenBank Accession No. NC_000008.9) NC_000008.9 should be changed to NM_178812.3 Thank you for your help. Sincerely Haiyan Liu read full comment
Comment on: Liu et al. Journal of Experimental & Clinical Cancer Research, 28:19
there are some revisions about paper (junjie wang, 14 February 2009)
there are some revision as follow: A.3.1: γray should be γ ray.
2. A.4.1: γ gamma rays should be γ ray.
3. B.11.1: γ rays should be γ ray in the third sentence and the last sentence of this paragraph.
4. B.11.1: (Table 1) in the fifth sentence should be moved to the end of the third sentence and before the full stop.
5. Legend of figure 3: but typical morphological features of apoptosis were appeared after …., were should be deleted here.
6. B.13.1: (Fig. 5 and Table 4) in the second sentence should be (Fig. 5 and Table 3).
7. B.18.1: His should be their in the first sentence.
Comment on: Zhuang et al. Journal of Experimental & Clinical Cancer Research, 28:12
NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues (Ibrahim Meteoglu, 11 February 2009)
Dear Editor, No corrections are needed of our article (MS: 2139278554214429 Title: NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues)Sincerely,Ibrahim Meteoglu
read full comment
Comment on: Meteoglu et al. Journal of Experimental & Clinical Cancer Research, 27:53
Correction (Mariam Vahdaninia, 11 February 2009)
Professor Montazeri found an unwanted mistake on his paper entitled ‘Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007’ published in Journal of Experimental & Clinical Cancer Research on last August (J Exp Clin Cancer Res 2008; 7: 32). He asked to post a comment as a correction statement to supplement the paper:<br>Unfortunately I have found a mistake on my paper that should be corrected. Under ‘Quality of life as predictor of survival’ the last paragraph reads as follows:<br>Similarly, Seidman et al. evaluated quality of life in two phase II clinical trials of metastatic breast cancer and found that baseline scores of two validated quality of life instruments independently predicted...
read full comment
Comment on: Montazeri Journal of Experimental & Clinical Cancer Research, 27:32
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Same panel in two different figures (Alessandro Fatatis, 19 February 2013)
It appears that figure 1B and figure 3A display the same set of data. read full comment
Comment on: Li et al. Journal of Experimental & Clinical Cancer Research, 31:102
Hybrid open-access, or still closed? (Yongsong Guan, 27 January 2013)
Hybrid open-access, or still... read full comment
Comment on: Poltronieri et al. Journal of Experimental & Clinical Cancer Research, 32:4
Claudin 5 in breast cancer (ylermi soini, 02 July 2012)
Dear... read full comment
Comment on: Escudero-Esparza et al. Journal of Experimental & Clinical Cancer Research, 31:43
Correction for 13C-NMR data of EPA (Colin Charles Duke, 20 March 2011)
The 15 numbers for the 13C-NMR data of EPA are, in error, shown in the article as being the same as EPD.
The correction is as follows:-
Eremophila-1(10),11(13)-dien-12-oic acid (EPA)
13C-NMR (CDCl3): 15.96, 20.71, 25.34, 27.00, 28.05, 30.41, 32.63, 36.24, 38.08, 40.50, 121.36, 124.72, 142.96, 145.12, 172.85.
read full comment
Comment on: van Haaften et al. Journal of Experimental & Clinical Cancer Research, 30:29
Mino error (QIUYAN WANG, 15 July 2010)
The legend of Figure 4 needs to be arranged. read full comment
Comment on: She et al. Journal of Experimental & Clinical Cancer Research, 29:93
INCIDENCE OF BREAST CANCER IN ITALY: WHY HOSPITALIZATION RECORDS ARE A VALUABLE OPPORTUNITY (Prisco Piscitelli, 20 July 2009)
Although Cancer Registries remain the gold standard for epidemiologic evaluation of tumors, unfortunately they are not currently available in all Italian provinces. Therefore, in order to evaluate the incidence of neoplastic lesions at national level (as declared in its publications), the Italian Association of Cancer Registries must use other data sources (such as mortality rates provided by the National Instiute for Statistics, ISTAT) or refer to average values determined within the few existing registries (actually 70% of Italian population is not being covered by cancer registries). This means that national data concerning the incidence of cancers in Italy are the result of average estimations or statistical models and do not reflect a real "count" of overall cases. On the other hand... read full comment
Comment on: Piscitelli et al. Journal of Experimental & Clinical Cancer Research, 28:86
Link to a lay summary of this research paper (Gustav Nilsonne, 20 July 2009)
A short non-technical description of this research is available on my blog at this link.
read full comment
Comment on: Nilsonne et al. Journal of Experimental & Clinical Cancer Research, 28:92
Trend assesment by comparison with a Cancer Registry (Paolo Contiero, 05 July 2009)
I have carefully read the paper, interesting because present a method to estimates breast cancer incidence, a so important topic for health service planning and primary prevention researches.
In my opinion, the weakness of this paper is the lack of a gold standard by which validate the method and its results. This could lead to the introduction of some bias in the estimates that are not possible to detect easily.
By this notes I show some data from the Cancer Registry of Varese and the hospital discharges of the same area.
The Cancer Registry of Varese began its activity in 1976 and its data was included in the last four editions of the Cancer Incidence in Five Continents.
The Cancer Registry data are linked with the hospital discharge (SDO), pathology report and... read full comment
Comment on: Piscitelli et al. Journal of Experimental & Clinical Cancer Research, 28:86
Answer to comments of prof. Koninckx (Alfonso Baldi, 07 June 2009)
Dear Editor,
We are very happy that our work is raising great interest in the scientific community (see for example Faculty of 1000 Medicine: evaluations for Signorile PG et al J Exp Clin Cancer Res 2009 28 :49 http://www.f1000medicine.com/article/id/1160737/evaluation).
We thank dr. Koninckx and colleagues for their comments on our paper supporting the embryological origin of endometriosis (1). Indeed, we have really appreciated some of the comments that will help us in our future investigations. Nevertheless, we strongly disagree with some of the claims of our colleagues. We will try to follow point-by-point their letter in order to clarify the issues raised.
The colleagues complain the absence of pictures or data of the endometrium. It is surprisingly that the colleagues... read full comment
Comment on: Signorile et al. Journal of Experimental & Clinical Cancer Research, 28:49
Ectopic endometrium in the human foetus (Müllerianosis) must be interpreted cautiously (Philippe R. Koninckx, 27 May 2009)
Dear Editor,
We read with great interest the nice observations by Signorile et al. of endometrium-like tissue in foetuses supporting the concept of müllerianosis. (1) The data, however, poorly support the speculative and overstretched conclusions. The title is misleading and the discussion partially incorrect.
In the absence of pictures or data of the endometrium and of the expression of estrogen receptors it is difficult to judge how specific this observation was. We therefore would be interested to have more information about the specificity of these markers and whether these markers were positive in all endometrium tissue. It is surprising not to find the word CA125, or the words ‘estrogen receptor’ in reference 1 quoted to support the choice of CA125 and of... read full comment
Comment on: Signorile et al. Journal of Experimental & Clinical Cancer Research, 28:49
Answer to the comment: Mulleriosis and not Mullerianosis by dr. Redwine (Alfonso Baldi, 14 May 2009)
Dear Editor,
we have really appreciated the positive comments of dr. Redwine on our paper recently published in your journal (J Exp Clin Cancer Res 2009; 28:49). We are very happy that our discoveries on the pathogenesis of endometriosis raise the interest of the other scientists involved in this field of research. Concerning the question raised by dr. Redwine on the exact term to use for defining this phenotype, we used the term Mullerianosis, because it is the one mostly used by researcher to define this condition, while the term Mulleriosis has been used only by dr. Redwine (Letter to Am J Obstet Gynecol 1987; 156:769); anyway we have no any problem in using also this term in our next publications. Nevertheless, we think that the most important point of our manuscript is, as also... read full comment
Comment on: Signorile et al. Journal of Experimental & Clinical Cancer Research, 28:49
Mulleriosis not Mullerianosis (David Redwine, 13 May 2009)
I read with great interest the recently published paper by Signorile
et al (1). They found evidence of endometriosis in 4 of 36 (11%) female
foetuses examined with step-sectioning of the posterior pelvis. They
correctly conclude that endometriosis begins in foetal life and is not
a product of reflux menstruation. Their work supports my work published
in 1988 (2), where I found apparent endometriosis in the cul de sac of
1 of 9 (11%) newborn females who died of sudden infant death syndrome,
although my work was not mentioned in the authors' reference list. I
would suggest that "Mulleriosis" would be a better term than
"Mullerianosis" for this ontogenic development. First, "Mulleriosis" as
an overarching term to describe the foetal... read full comment
Comment on: Signorile et al. Journal of Experimental & Clinical Cancer Research, 28:49
GenBank Accession No should be corrected (Haiyan Liu, 26 February 2009)
Dear editor,
I’ m sorry for my mistake.
B 4.1 Knockdown of AEG-1 expression was achieved using transfection of AEG-1-siRNA. AEG-1-siRNA1 and AEG-1-siRNA2 targeting nucleotides 971-991 and 1355-1375 of human AEG-1 mRNA sequence (GenBank Accession No. NC_000008.9) NC_000008.9 should be changed to NM_178812.3
Thank you for your help.
Sincerely
Haiyan Liu
read full comment
Comment on: Liu et al. Journal of Experimental & Clinical Cancer Research, 28:19
there are some revisions about paper (junjie wang, 14 February 2009)
there are some revision as follow:
A.3.1: γray should be γ ray.
2. A.4.1: γ gamma rays should be γ ray.
3. B.11.1: γ rays should be γ ray in the third sentence and the last sentence of this paragraph.
4. B.11.1: (Table 1) in the fifth sentence should be moved to the end of the third sentence and before the full stop.
5. Legend of figure 3: but typical morphological features of apoptosis were appeared after …., were should be deleted here.
6. B.13.1: (Fig. 5 and Table 4) in the second sentence should be (Fig. 5 and Table 3).
7. B.18.1: His should be their in the first sentence.
read full comment
Comment on: Zhuang et al. Journal of Experimental & Clinical Cancer Research, 28:12
the paper about 125I seed (junjie wang, 11 February 2009)
no .it is ok. read full comment
Comment on: Zhuang et al. Journal of Experimental & Clinical Cancer Research, 28:12
NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues (Ibrahim Meteoglu, 11 February 2009)
Dear Editor, No corrections are needed of our article (MS: 2139278554214429 Title: NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues)Sincerely,Ibrahim Meteoglu read full comment
Comment on: Meteoglu et al. Journal of Experimental & Clinical Cancer Research, 27:53
Correction (Mariam Vahdaninia, 11 February 2009)
Professor Montazeri found an unwanted mistake on his paper entitled ‘Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007’ published in Journal of Experimental & Clinical Cancer Research on last August (J Exp Clin Cancer Res 2008; 7: 32). He asked to post a comment as a correction statement to supplement the paper:<br>Unfortunately I have found a mistake on my paper that should be corrected. Under ‘Quality of life as predictor of survival’ the last paragraph reads as follows:<br>Similarly, Seidman et al. evaluated quality of life in two phase II clinical trials of metastatic breast cancer and found that baseline scores of two validated quality of life instruments independently predicted... read full comment
Comment on: Montazeri Journal of Experimental & Clinical Cancer Research, 27:32