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1: Appl Radiat Isot. 2007 Jan;65(1):120-5. Epub 2006 Sep 25.
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Experimental determination of calibration settings of a commercially available radionuclide calibrator for various clinical measurement geometries and radionuclides.

Ceccatelli A, Benassi M, D'Andrea M, De Felice P, Fazio A, Nocentini S, Strigari L.

Laboratorio di Fisica Medica e Sistemi Esperti, Regina Elena National Cancer Institute, via E. Chianesi, 53 - 00144 Rome, Italy. alessia.ceccatelli@tiscali.it

Following the approach of the National Primary Laboratory of the UK (NPL) for the calibration of radionuclide calibrators, but using a commercially available instrument with no data available in the literature, the radionuclide calibrator response was investigated as a function of different measurement geometries at the "Regina Elena" National Cancer Institute (IRE) in Rome. Working with Italian National Metrology Institute for ionising radiation quantities (ENEA-INMRI), specific calibration factors with traceability to national primary standards were determined for different types of glass vials, solid capsules and plastic syringes, investigating three radionuclides with different energy spectra (Tc-99m, In-111, I-131). For each kind of syringe, calibration correction factors for different filling volumes were calculated. For Tc-99m and I-131 the difference between measured and true activity was in the range 2-7%, depending on measurement geometry. For In-111 a large percentage deviation from the true activity value was found in each geometry considered, reaching 35%. The magnitude of this difference is particularly dependent on the energies of the emitted photons.

PMID: 16996744 [PubMed - indexed for MEDLINE]